Rush-hour for neutrophils

LMU researchers have shown that circadian oscillations in the influx of immune cells into the damaged tissue play a crucial role in exacerbating the effects of an acute heart attack in the early morning hours.

The extent of the inflammatory reaction triggered by an acute heart attack, and of the resulting damage to the heart muscle, varies depending on the time of day at which the infarct occurs. In a new study, researchers led by Sabine Steffens , Professor of Clinical Pathobiochemistry in the Institute for Cardiovascular Prevention (IPEK) at the LMU Medical Center confirm that the intensity of the immune reaction is correlated with the level of recruitment of immune cells called neutrophilic granulocytes to the damaged heart. ...
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