A look at the molecular quality assurance within cells

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A look at the molecular quality assurance within cells. (Illustration: Joshua St
A look at the molecular quality assurance within cells. (Illustration: Joshua Stokes, St. Jude Children’s Research Hospital)
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Proteins fulfill vital functions in our body. They transport substances, combat pathogens, and function as catalysts. In order for these processes to function reliably, proteins must adopt a defined three-dimensional structure. Molecular "folding assistants", called chaperones, aid and scrutinize these structuring processes. With participation from the Technical University of Munich (TUM), a team of researchers has now revealed how chaperones identify particularly harmful errors in this structuring process.


Chaperones are a kind of Technical Inspection Authority for cells. They are proteins that inspect other proteins for quality defects before they are allowed to leave the cell. ...
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