Post-Doctoral Researcher - Metabolomics

WorkplaceZurich, Zurich region, Switzerland


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80%-100%, Zurich, fixed-term

The Institute of Molecular Systems Biology at ETH Zurich is inviting applications for a Postdoctoral position in the laboratory of Professor Dr Nicola Zamboni .

Project background

The group of Dr Zamboni researches the function and regulation of metabolism. In particular, the group is attracted by

  • systems in which metabolism or metabolites drive phenotypic differentiation
  • problems of biomedical relevance, and
  • cases that are especially complex or technically challenging

To tackle such problems, the group adopts cutting-edge mass spectrometry (i.e. metabolomics, lipidomics, and quantitative 13C metabolic flux analysis) and computational methods. The latter range from statistics to deep learning or probabilistic graphical models, and aim at integrating prior knowledge on molecular properties or network topology.

A key focus of the group is on the development of high-throughput methods, which allow to rapidly screen large cohorts of, i.e. clinical samples, drug libraries, or mutant collections. By combining high-resolution, untargeted mass spectrometry and newly engineered software pipelines, the group has become very efficient in analyzing studies with tens of thousands of samples without compromising quality and coverage. Beyond internal R&D projects, the group of Dr Zamboni is heavily involved in external collaborations, both national and international. The group is tightly embedded in the Swiss initiatives on personalized health (PHRT, ?" target="_blank" rel="nofollow"> ). In the near term, the priority challenges are on generating interoperable data across studies, improving the acquisition of possibly informative and deep MS2 data, and enabling the detection of rare compounds.

Job description

  • contribute on LC-MS method development, with a particular focus on novel DIA and DDA workflows.
  • contribute in building a full service portfolio for clinical and biomedical research.
  • conduct MS analyses on various systems (TOFs and Orbitraps, LC and sporadically GC).
  • participate in instrument maintenance.
  • synergize with team members, collaborators, and vendors.
  • participate in teaching activities.

Your profile

  • a genuine passion for metabolomics
  • a doctoral degree in analytical chemistry or a related field.
  • strong background in mass spectrometry and liquid chromatography
  • excellent technical skills in LC-HRMS, with hands-on experience in routine maintenance.
  • a proactive personality and excellent communication skills.

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
Working, teaching and research at ETH Zurich

In your application, please refer to and reference JobID 168361.

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