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News from the Lab (news.myScience.ch)

  • News from the Lab’ is a selection of scientific works that are significant or interesting for a broad readership. 
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Pharmacology



Results 1 - 20 of 90.
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Pharmacology - Health - 05.05.2022
Small changes - but essential! How peptides are recognised in receptors
Small changes - but essential! How peptides are recognised in receptors
Researchers discover molecular mechanisms of signal recognition of the neuropeptide system The human body consists of trillions of cells that constantly communicate with each other. A central role in this communication process is played by receptor proteins on the cell surface. Since they often serve as drug targets, they have been the subject of intensive research.

Health - Pharmacology - 28.04.2022
Vaccination campaign messages often prove ineffective
Vaccination campaign messages often prove ineffective
Conventional vaccination campaign messages often miss their targets. A study in eight European countries shows that information on the benefits of vaccines can even reduce the willingness to get immunized. The researchers also looked into the factors that influenced the impact of messages, including low health literacy.

Health - Pharmacology - 26.04.2022
Liver fibrosis: the fatal signalling pathway
MHH research team clarifies how liver inflammation and scarring of liver tissue are connected At least five million people in Germany suffer from liver disease. Fibrosis, the pathological proliferation of connective tissue, plays an important role in many complications of chronic liver problems. Activated hepatic stellate cells (HSCs) are massively involved in this tissue remodelling.

Health - Pharmacology - 13.04.2022
COVID-19 therapy: better in combination than alone
How a well-known drug can become a game changer - A joint press release by Charité, the MDC and FU Berlin There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité - Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.

Health - Pharmacology - 05.04.2022
Researcher wants to stop harmful effect of chemotherapy on heart muscle
EU funds research project to elucidate pathological cardiac remodelling caused by cancer drugs with around 2.5 million euros 04. Heart failure is one of the most common causes of death worldwide. The disease, known in medicine as cardiac insufficiency, affects about four million people in Germany.

Pharmacology - Health - 25.03.2022
Bioactive substance inhibits important receptor
Bioactive substance inhibits important receptor
Study shows how bioactive substance inhibits important receptor Study shows how bioactive substance inhibits important receptor Results from the University of Bonn raise hope for new drugs against cancer and brain diseases The A2A receptor regulates how vigorously the innate immune system attacks diseased cells.

Health - Pharmacology - 22.03.2022
The right diet can safeguard against acute kidney injury
A research team led by Professor Dr Roman-Ulrich Müller has established that four out of six different nutritional strategies prevent acute kidney injury in the mouse model. Furthermore, the team identified a potential mechanism protecting the organs in their interdisciplinary, translational study. This is the first step towards transferring the results from bench to bedside.

Life Sciences - Pharmacology - 21.03.2022
Brain stimulation shows beneficial effects for motor deficits following stroke
Brain stimulation shows beneficial effects for motor deficits following stroke
This promising non-invasive method can be used for rehabilitation, provided that an individualised approach is developed Persistent paralysis and coordination problems are among the most common consequences of a stroke. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, the University Medical Center Halle, and the Charité -Universitätsmedizin in Berlin have discovered that brain stimulation helps.

Health - Pharmacology - 18.03.2022
No benefit from hemoadsorption in endocarditis surgery
No benefit from hemoadsorption in endocarditis surgery
In a controlled multicenter trial, a research team from Jena University Hospital investigated the benefit of hemoadsorption during cardiac surgery, aimed at reducing blood levels of inflammatory mediators, on clinical outcome. The study, now presented in Circulation, shows that hemoadsorption reduced plasma cytokines during surgery, but did not affect any of the clinically relevant outcomes.

Pharmacology - Life Sciences - 10.03.2022
Toolbox for systematic study of receptor regulation
Toolbox for systematic study of receptor regulation
Researchers from Jena and Bonn have developed a cell system to analyze the regulation of G protein-coupled receptors. To prevent overstimulation, these pharmacologically important receptors can be inactivated by specific enzymes inside the cell. That desensitization mechanism is suspected of playing a crucial role for habituation on painkillers or anti-asthmatics.

Life Sciences - Pharmacology - 18.02.2022
Plants Under Anaesthesia
Plants Under Anaesthesia
02/18/2022 The carnivorous Venus flytrap can be anaesthetised with ether. Some surprising parallels to anaesthesia in humans emerge. Medicine has a broad repertoire of anaesthetics at its medication allows patients to better endure painful treatments or even sleep through them. As early as 1842, ether was first used for a dental treatment in New York.

Health - Pharmacology - 17.02.2022
New organ-on-chip system enables precise monitoring of 3D tumour tissue outside the body
New organ-on-chip system enables precise monitoring of 3D tumour tissue outside the body
3D tissue structures on the chip act as organs in miniature A research team around Andreas Weltin, Dr. Jochen Kieninger and Johannes Dornhof from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg has developed a system that, among other things, makes it possible to study the development of tumour cells outside the human body in a three-dimensional environment.

Health - Pharmacology - 14.02.2022
Mechanism of Cerebral Venous Thrombosis Discovered
Mechanism of Cerebral Venous Thrombosis Discovered
02/14/2022 Cerebral venous thrombosis is a rare, often severe disease that has been brought to public attention by the Covid 19 pandemic. Researchers have now succeeded for the first time in deciphering a molecular cause of this disease. Cerebral venous thrombosis is a rare form of cerebral circulatory disorder that, unlike classic stroke, more often affects younger people.

Health - Pharmacology - 11.02.2022
Chemotherapy or not? Physicists study gene expression tests
Following surgery, patients with breast cancer are faced with the question of whether additional chemotherapy is necessary and really effective. It is important that these women do not receive too much treatment - but not too little treatment either. Physicists from Leipzig University modelled the gene expression tests and examined their usefulness on the basis of these models.

Health - Pharmacology - 03.02.2022
'Inflaming' cold tumors
’Inflaming’ cold tumors
Pancreatic carcinoma is a tumor with an extremely poor prognosis for which effective treatments have not yet been found. In a preclinical animal model with mice, a team of researchers has now discovered a way of making pancreatic tumors treatable with immunotherapy methods using a targeted combination of two cancer drugs.

Health - Pharmacology - 01.02.2022
Covid-19: Three exposures needed for broad immunity
Covid-19: Three exposures needed for broad immunity
Number of exposures to viral spike protein crucial for effective antibody response The immune system develops a high-quality antibody response after three encounters with the coronavirus spike protein. These antibodies are also capable of neutralizing Omicron efficiently. This applies to people who are triple-vaccinated, to those having recovered and then received two vaccinations and to double-vaccinated individuals who have experienced a breakthrough infection.

Health - Pharmacology - 14.01.2022
New dual benefit mode of action for a drug candidate to fight Covid-19
New dual benefit mode of action for a drug candidate to fight Covid-19
A research team led by Prof. Stephan Ludwig, a virologist at the Institute of Virology at the University of Münster, has found a new dual attack mode of action while working on the development of a drug candidate against SARS-CoV-2 infections. This could constitute the basis for a broadly effective drug to fight Covid 19.

Health - Pharmacology - 04.01.2022
Why Sentinel Cells are so Important
Why Sentinel Cells are so Important
The presence of sentinel immune cells is vital to maintain and regulate the balance of the body's immune response. Researchers have discovered an essential role of these cells in the treatment of cancer and severe viral infections. Chronic viral infections and cancers can cause a permanent impairment to the immune system, reducing the ability of immune killer T cells to remove tumour cells, or those infected by a virus - this is referred to as 'immune exhaustion'.

Physics - Pharmacology - 27.12.2021
Optimization of mRNA containing nanoparticles
Optimization of mRNA containing nanoparticles
The research neutron source Hein Maier-Leibnitz (FRM II) at the Technical University of Munich (TUM) is playing an important role in the investigation of mRNA nanoparticles similar to the ones used in the Covid-19 vaccines from vendors BioNTech and Pfizer. Researchers at the Heinz Maier-Leibnitz Zentrum (MLZ) used the high neutron flux available in Garching to characterize various formulations for the mRNA vaccine and thus to lay the groundwork for improving the vaccine's efficacy.

Pharmacology - Health - 30.11.2021
'Discussions with manufacturers often get nowhere'
’Discussions with manufacturers often get nowhere’
Food supplements are available in a lot of places - in drugstores, health food shops, pharmacies and on the Internet - and the market is booming. Many of these products contain plant extracts whose ingredients are supposed to have healthy benefits - provided they do actually contain what they claim. Because nowhere near all of these so-called botanicals deliver what they promise.
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