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Health - Life Sciences - 10.03.2023 
Immune cells have a backup mechanism
If the TBK1 enzyme is mutated, susceptibility to viral infections increases - unless it is missing The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections.
Health - Life Sciences - 09.03.2023
Health - Life Sciences - 09.03.2023
Life Sciences - Health - 09.03.2023 
Major advance in super-resolution fluorescence microscopy
Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
Health - Life Sciences - 08.03.2023 
Altered brain structure: Why infections during pregnancy can promote autism
Important decisions are made early in life - some even before birth. Already in the womb, environmental factors influence the child's development and can have an impact on health. For example, certain infections increase the risk of developing an autism spectrum disorder later on. A research team led by Dr. Simone Mayer of the Hertie Institute for Clinical Brain Research and the University of Tübingen has now deciphered a molecular mechanism of this connection.
Life Sciences - Health - 08.03.2023 
Deeper insights into bacteria
RNA sequencing technologies provide valuable insights into how individual cells work. A research team at the University of Würzburg has now developed a technique that provides an even more detailed view. How do cells work in a normal state? How do they change when they cause disease? Do they react as desired to new drugs? Nowadays, anyone seeking answers to these - and other related - questions in the laboratory can hardly do without a special technique: single-cell RNA sequencing, or "scRNA-seq" for short.
Life Sciences - Health - 03.03.2023
Life Sciences - Health - 03.03.2023 
Putting out the fire in the brain
In autoimmune encephalitis, a rare but serious and sometimes life-threatening inflammation of the central nervous system, the body's own defences are directed against the central nervous system. This disease was first identified in 2007, and the most common type is Anti-NMDA receptor encephalitis. In this autoimmune disease, a protein that plays an important role in signal transmission in the brain is disrupted: the NMDA-type glutamate receptor, or NMDA receptor for short.
Psychology - Health - 01.03.2023
Health - Life Sciences - 01.03.2023 
Pseudomonas aeruginosa Bacteria produce a molecule that paralyzes immune system cells
Researchers from Freiburg and Strasbourg have discovered a strong immunological effect of the molecule LecB - and a way to prevent it. Bacteria of the species Pseudomonas aeruginosa are antibiotic-resistant hospital germs that can enter blood, lungs and other tissues through wounds and cause life-threatening infections.
Health - Pharmacology - 01.03.2023 
Artificial intelligence to help tumor immunology
Researchers want to study the environment of cancer cells in more detail. Federal Ministry of Education and Research funds project with 800,000 euros The success of cancer treatment depends not only on the type of tumor, but also on the surrounding tissue. Tumors influence it to their advantage, promoting the growth of blood vessels or fooling incoming immune cells.
Health - Life Sciences - 01.03.2023 
Gut bacteria are crucial for liver repair
Microbiome provides important building blocks for cell division When parts of the liver are removed, the body can replace the missing tissue. A team of researchers at the Technical University of Munich (TUM) has now discovered that the success of this process depends to a large extent on gut bacteria.
Health - Economics - 24.02.2023 
Research team calls for stricter regulation of breast milk substitutes
Most health and nutrition claims on food products for infants, i.e. substitutes for breast milk, are hardly or not at all supported by high-quality scientific evidence. This is the conclusion of an international study from 15 countries in which scientists from Leipzig University Hospital took part.
Health - Life Sciences - 24.02.2023 
The Achilles heel of the influenza virus
Researchers at Münster University suggest a new approach to active ingredients to fight influenza Every year, the influenza season presents a challenge to hospitals. Despite having been vaccinated, older people and patients with health problems in particular run a heightened risk of falling prey to a severe bout of influenza.
Health - 21.02.2023 
Sugar reduction in soft drinks making no progress
Study investigates the success of measures in Germany and the United Kingdom Soft drinks are seen as major factors in obesity and diabetes. A new study shows: In Germany the mean sugar content has hardly dropped over the last six years, in spite of guarantees on the part of the industry. In the United Kingdom, where a soft drink industry levy was introduced in 2018, a significantly greater reduction was achieved during the same period of time.
Health - Life Sciences - 13.02.2023 
Tracking down leaks in the blood-brain barrier
Bonn researchers develop new method to study selective diffusion barrier In epilepsy research, it has long been assumed that a leaky blood-brain barrier is a cause of inflammation in the brain. Using a novel method, researchers from the University of Bonn an the Bonn University Hospital (UKB) have demonstrated that the barrier between the blood and the central nervous system remains largely intact.
Health - 13.02.2023 
Covid-19 Measures: How Strict Do They Need To Be?
Study on the effectiveness of restrictions takes citizens' behavioral changes into account After about three years of the Covid-19 pandemic, policy makers and citizens alike are still struggling to find the best way to deal with the virus. Measures need to be effective, but also socially acceptable.
Life Sciences - Health - 09.02.2023 
Less is more
Scientists from Würzburg and Braunschweig have developed a new approach that enables more efficient processing of bacterial genomes . The ability to genetically modify bacteria is key to exploring the microbial world. Genome editing - the editing of genetic material such as DNA - is essential for developing new antibiotics and using bacteria as miniature factories for the sustainable production of chemicals, materials and therapeutics.
Health - Life Sciences - 09.02.2023 
New compound inhibits influenza virus replication
Researchers from the University of Bonn: Derivative of a bacterial natural product blocks endogenous methyltransferase Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza.
Life Sciences - Health - 08.02.2023 
Protein droplets may cause many types of genetic disease
Malfunction of cellular condensates is a disease mechanism relevant for congenital malformations, common diseases, and cancer Most proteins localize to distinct protein-rich droplets in cells, also known as "cellular condensates". Such proteins contain sequence features that function as address labels, telling the protein which condensate to move into.
Health
Results 61 - 80 of 701.
If the TBK1 enzyme is mutated, susceptibility to viral infections increases - unless it is missing The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections.
French-German Team Refutes Standard Model of Electroporation
Technology developed at University of Freiburg enables experimental test Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.
Technology developed at University of Freiburg enables experimental test Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.
New stem cell model developed for research into a life-threatening malformation of the newborn lung
Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
Important decisions are made early in life - some even before birth. Already in the womb, environmental factors influence the child's development and can have an impact on health. For example, certain infections increase the risk of developing an autism spectrum disorder later on. A research team led by Dr. Simone Mayer of the Hertie Institute for Clinical Brain Research and the University of Tübingen has now deciphered a molecular mechanism of this connection.
RNA sequencing technologies provide valuable insights into how individual cells work. A research team at the University of Würzburg has now developed a technique that provides an even more detailed view. How do cells work in a normal state? How do they change when they cause disease? Do they react as desired to new drugs? Nowadays, anyone seeking answers to these - and other related - questions in the laboratory can hardly do without a special technique: single-cell RNA sequencing, or "scRNA-seq" for short.
DFG Research Unit Develops a Potential Treatment for Autoimmune Encephalitis
In autoimmune encephalitis, a rare but serious and sometimes life-threatening inflammation of the central nervous system, the body's own defences are directed against the central nervous system. This disease was first identified in 2007, and the most common type is Anti-NMDA receptor encephalitis. In this autoimmune disease, a protein that plays an important role in signal transmission in the brain is disrupted: the NMDA-type glutamate receptor, or NMDA receptor for short.
In autoimmune encephalitis, a rare but serious and sometimes life-threatening inflammation of the central nervous system, the body's own defences are directed against the central nervous system. This disease was first identified in 2007, and the most common type is Anti-NMDA receptor encephalitis. In this autoimmune disease, a protein that plays an important role in signal transmission in the brain is disrupted: the NMDA-type glutamate receptor, or NMDA receptor for short.
In autoimmune encephalitis, a rare but serious and sometimes life-threatening inflammation of the central nervous system, the body's own defences are directed against the central nervous system. This disease was first identified in 2007, and the most common type is Anti-NMDA receptor encephalitis. In this autoimmune disease, a protein that plays an important role in signal transmission in the brain is disrupted: the NMDA-type glutamate receptor, or NMDA receptor for short.
Traumas in children and adolescents can be treated effectively
Meta-analysis carried out by psychologists confirms efficacy of trauma-focused therapy / Study published in British Journal of Psychiatry Psychotherapeutic treatment based on trauma-focused therapy is highly effective for children and adolescents who have experienced repeated traumatic events such as sexual, physical or emotional abuse.
Meta-analysis carried out by psychologists confirms efficacy of trauma-focused therapy / Study published in British Journal of Psychiatry Psychotherapeutic treatment based on trauma-focused therapy is highly effective for children and adolescents who have experienced repeated traumatic events such as sexual, physical or emotional abuse.
Researchers from Freiburg and Strasbourg have discovered a strong immunological effect of the molecule LecB - and a way to prevent it. Bacteria of the species Pseudomonas aeruginosa are antibiotic-resistant hospital germs that can enter blood, lungs and other tissues through wounds and cause life-threatening infections.
Researchers want to study the environment of cancer cells in more detail. Federal Ministry of Education and Research funds project with 800,000 euros The success of cancer treatment depends not only on the type of tumor, but also on the surrounding tissue. Tumors influence it to their advantage, promoting the growth of blood vessels or fooling incoming immune cells.
Microbiome provides important building blocks for cell division When parts of the liver are removed, the body can replace the missing tissue. A team of researchers at the Technical University of Munich (TUM) has now discovered that the success of this process depends to a large extent on gut bacteria.
Most health and nutrition claims on food products for infants, i.e. substitutes for breast milk, are hardly or not at all supported by high-quality scientific evidence. This is the conclusion of an international study from 15 countries in which scientists from Leipzig University Hospital took part.
Researchers at Münster University suggest a new approach to active ingredients to fight influenza Every year, the influenza season presents a challenge to hospitals. Despite having been vaccinated, older people and patients with health problems in particular run a heightened risk of falling prey to a severe bout of influenza.
Study investigates the success of measures in Germany and the United Kingdom Soft drinks are seen as major factors in obesity and diabetes. A new study shows: In Germany the mean sugar content has hardly dropped over the last six years, in spite of guarantees on the part of the industry. In the United Kingdom, where a soft drink industry levy was introduced in 2018, a significantly greater reduction was achieved during the same period of time.
Bonn researchers develop new method to study selective diffusion barrier In epilepsy research, it has long been assumed that a leaky blood-brain barrier is a cause of inflammation in the brain. Using a novel method, researchers from the University of Bonn an the Bonn University Hospital (UKB) have demonstrated that the barrier between the blood and the central nervous system remains largely intact.
Study on the effectiveness of restrictions takes citizens' behavioral changes into account After about three years of the Covid-19 pandemic, policy makers and citizens alike are still struggling to find the best way to deal with the virus. Measures need to be effective, but also socially acceptable.
Scientists from Würzburg and Braunschweig have developed a new approach that enables more efficient processing of bacterial genomes . The ability to genetically modify bacteria is key to exploring the microbial world. Genome editing - the editing of genetic material such as DNA - is essential for developing new antibiotics and using bacteria as miniature factories for the sustainable production of chemicals, materials and therapeutics.
Researchers from the University of Bonn: Derivative of a bacterial natural product blocks endogenous methyltransferase Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza.
Malfunction of cellular condensates is a disease mechanism relevant for congenital malformations, common diseases, and cancer Most proteins localize to distinct protein-rich droplets in cells, also known as "cellular condensates". Such proteins contain sequence features that function as address labels, telling the protein which condensate to move into.
