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Health - Pharmacology - 16.05.2024
Pathoblockers, a Future Alternative to Antibiotics’
Researchers at Freie Universität Berlin and Charité - Universitätsmedizin Berlin "defanging" bacteria, rendering them harmless In most cases, antibiotics are a reliable form of protection against bacterial infections. They have saved billions of human lives since their introduction. This protection, however, is threatened by bacteria's resistance to classical antibiotics and by their aggressive pathogenicity.

Pharmacology - Life Sciences - 16.05.2024
A Second Chance for New Antibiotic Agent
Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective. An increasing number of bacteria have become resistant to many commonly used antibiotics. Researchers from Bochum have discovered a fresh opportunity for a potential active molecule whose predecessor was rejected: By studying its interaction with the bacterial target protein very precisely in three dimensions, they identified a previously undetected point of attack that could be targeted by this compound.

Pharmacology - Health - 15.05.2024
Study Paves the Way for an Active Agent Against Hepatitis E
A newly identified compound prevents a cellular enzyme from cleaving the virus particle. As a result, the virus can no longer infect cells. At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one.

Health - Pharmacology - 29.04.2024
Possible alternative to antibiotics produced by bacteria
Possible alternative to antibiotics produced by bacteria
Antibacterial substance from staphylococci discovered with new mechanism of action against natural competitors Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the German Center for Infection Research (DZIF) have discovered a new so-called lantibiotic, namely epilancin A37.

Health - Pharmacology - 24.04.2024
Tumor cells evade the immune system early on
Tumor cells evade the immune system early on
Newly discovered mechanism could significantly improve cancer immunotherapies Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers at the Technical University of Munich (TUM) and the Ludwig-Maximilians-Universität München (LMU) Hospital have now uncovered for the first time how this exactly happens.

Health - Pharmacology - 24.04.2024
Biomarkers identified for successful treatment of bone marrow tumours
CAR T cell therapy has proven effective in treating various haematological cancers. However, not all patients respond equally well to treatment. In a recent clinical study, researchers from the University of Leipzig Medical Center and the Fraunhofer Institute for Cell Therapy and Immunology identified several biomarkers that are associated with the response to CAR T cell therapy in multiple myeloma, a malignant tumour disease in the bone marrow.

Life Sciences - Pharmacology - 15.04.2024
An enzyme makes mushrooms 'magical'
An enzyme makes mushrooms ’magical’
An international research team has investigated the biosynthesis of psilocybin, the main ingredient of hallucinogenic mushrooms. They gained new insights into the structure and reaction mechanism of the enzyme PsiM. It plays a key role in the production of psilocybin. The results of the study were published in the journal "Nature Communications".

Chemistry - Pharmacology - 10.04.2024
New strategy for assessing the applicability of reactions
New strategy for assessing the applicability of reactions
Team from the University of Münster presents computer-aided method / Counteracting subjective bias in studies on the production of new chemical compounds Chemists often develop and optimise new chemical reactions using so-called model systems, i.e. simple, easily accessible substrates.

Health - Pharmacology - 08.04.2024
Histopathological biomarkers for nanomedicine-based cancer therapy
Researchers from the Institute of Experimental Molecular Imaging at RWTH Aachen University publish results on the identification of suitable tumor patients in clinical trials for nanoparticle-based cancer therapies . Nanomedical formulations have attracted increasing public attention since the development of coronavirus vaccines.

Health - Pharmacology - 01.03.2024
Too much niacin increases the risk of cardiovascular disease
Too much niacin increases the risk of cardiovascular disease
Too much niacin increases the risk of cardiovascular disease Niacin, also known as vitamin B3, is freely available as a dietary supplement . Why do some people have an increased risk of heart attack and stroke even without classic risk factors such as high cholesterol? An international research team has taken an open-ended look at what circulates in the bloodstream of affected people and distinguishes them from others.

Health - Pharmacology - 27.02.2024
New Study on the Benefits of Covid-19 Nasal Spray Vaccination Published in ’Nature Communications’
Joint research led by scientists at Freie Universität Berlin reaches another milestone Rocketvax AG, together with the German Research Foundation (DFG), has financially supported a study carried out as part of a joint project of the Swiss National Science Foundation (SNSF, National Research Program "Covid-19," NRP 78) and the German Research Foundation (DFG) "Recoding the SARS-CoV-2 Genome - A Multidisciplinary Approach to Generate Live-Attenuated Coronavirus Vaccines.

Chemistry - Pharmacology - 19.02.2024
Turning One into Eight
Turning One into Eight
University of Bonn chemists invent technique for producing variants of natural substances To synthesize potential drugs or natural products, you need natural substances in specific mirror-image variants and with a high degree of purity. For the first time, chemists at the University of Bonn have succeeded in producing all'eight possible variants of polypropionate building blocks from a single starting material in a relatively straightforward process.

Life Sciences - Pharmacology - 08.02.2024
Pharmacological Inhibitor Protects Nerve Cells in ALS Disease
Heidelberg neurobiologists successfully test novel drug principle in a mouse model and in brain organoids of ALS patients A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

Health - Pharmacology - 31.01.2024
Precursor of Cholesterol Protects Cells From Ferroptosis
Precursor of Cholesterol Protects Cells From Ferroptosis
A precursor of cholesterol, previously categorised as harmful, can protect cancer cells from cell death. This finding, published in Nature, opens new doors for cancer research. In a groundbreaking study, a team led by Würzburg Professor José Pedro Friedmann Angeli has shown that the cholesterol precursor 7-dehydrocholesterol (7-DHC) plays a crucial role as an antioxidant: it integrates into the cell membranes and protects the cells by preventing a certain type of cell death, known as ferroptosis.

Pharmacology - Life Sciences - 31.01.2024
Detecting Hepatitis Viruses in Wastewater
Detecting Hepatitis Viruses in Wastewater
Researchers have identified genetic traces of hepatitis E viruses in almost 73 percent of wastewater samples from North-Rhine Westphalia. Findings on drug-resistant variants are of particular value. Hepatitis E is widespread among the population worldwide. The World Health Organization estimates that around 20 million people are infected with it every year.

Health - Pharmacology - 30.01.2024
Elimination of drug resistance
Bonn researchers discover that a protein from fatty tissue precursors is the cause of treatment failure and develop a solution strategy Urothelial carcinomas are malignant tumors that originate from the epithelium that lines the bladder and ureters, for example. They are still one of the most common types of cancer in Europe, especially in men.

Health - Pharmacology - 23.01.2024
Mutating Hepatitis Viruses Make Drug Treatment More Difficult
Mutating Hepatitis Viruses Make Drug Treatment More Difficult
A combination therapy with multiple drugs is more effective than just one active compound. To begin with, at least. Hepatitis E affects over 20 million people worldwide. It clears up without any consequences in most cases, but it can pose a risk to pregnant women and immunocompromised patients. There are no specific active substances against the virus.

Health - Pharmacology - 17.01.2024
Early detection of breast cancer
Early detection of breast cancer
Further TOSYMA analysis underpins advantages of DBT+SM use compared to the previous screening standard In diagnostics, finding more is not automatically better. Rather, it is about finding the right thing - especially in the case of such dangerous diseases as cancer. This is where early detection comes into play, but it can also have unwanted side effects: For example, there is a risk of also discovering non-aggressive tumors that lead to treatment - but would not have substantively impaired quality of life or become life-threatening in the course of the disease.

Psychology - Pharmacology - 12.01.2024
Psychotherapy effective in treating post-traumatic stress disorder following multiple traumatic events: International meta-study
Psychotherapy effective in treating post-traumatic stress disorder following multiple traumatic events International meta-study: Team led by researchers from the University of Münster reports encouraging results for patients and therapists Psychotherapy is an effective treatment for adults with post-traumatic stress disorder (PTSD) following exposure to multiple traumatic events.

Life Sciences - Pharmacology - 12.01.2024
Cause of listlessness in depression discovered
Cause of listlessness in depression discovered
Lack of activation of the locus coeruleus in the brain inhibits the inner drive Researchers at the Max Planck Institute of Psychiatry in Munich, Germany,  have discovered that the dilation of the pupil in response to an expected reward depends on whether a person can feel pleasure. This indicates that insufficient activity of the locus coeruleus in the brain is largely responsible for the lack of drive in people with depression.