Hard to drug

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Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate cancer

Super-resolution (τ-STED) imaging of the androgen receptor in human prostate
Super-resolution (τ-STED) imaging of the androgen receptor in human prostate adenocarcinoma cells. © MPI for Molecular Genetics
Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge. An international team of researchers from the Institute for Research in Biomedicine in Barcelona, the Max Planck Institute for Molecular Genetics, BC Cancer (University of British Columbia) and other institutions has now discovered a potential way to target the androgen receptor, the most prominent oncogenic transcription factor in prostate cancer, based on its propensity to form droplets also known as condensates. ...
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