Synthesis of isoquinuclidines by using the blue LED-enabled photochemistry
Some of the most biologically active molecules, including synthetic drugs, contain a central, nitrogen-containing chemical structure called an isoquinuclidine. This core has a three-dimensional shape which means it has the potential to interact more favourably with enzymes and proteins than flat, two-dimensional molecules. Unfortunately methods to make isoquinuclidines and the related dehyrdoisoquinuclidines suffer from a number of drawbacks which make it more difficult for scientists to discover new medicinal compounds. A team of researchers led by Prof. Frank Glorius at the University of Münster have now published a new method of enabling this reaction. The study was published in the journal “Chem”.
...TO READ THIS ARTICLE, CREATE YOUR ACCOUNT
And extend your reading, free of charge and with no commitment.
