2 PhD Positions in Molecular Parasitology
Project 1: Functional characterization of proteins involved in chromosome segregation in the human pathogen Trypanosoma brucei.
The protozoan parasite Trypanosoma brucei, causative agent of sleeping sickness in Africa, evades the human immune system by constantly changing its surface antigens, a process known as antigenic variation. A large reservoir of genes coding for these surface antigens is located on a specialized set of chromosomes. Very little is known about mechanisms that ensure their stability and faithful segregation during mitosis. The aim of this project is to identify and characterize proteins involved in these processes. We use a wide range of molecular, biochemical and cell biological methods to address these questions.
Project 2: The role of kinesin motorproteins in organelle maintenance and cellular morphogenesis in the human pathogen Trypanosoma brucei.
Trypanosomes have a highly organised microtubule-based cytoskeleton. It is involved in many fundamental cellular processes such as the determination of cellular morphology, intracellular transport, anchoring and maintenance of organelles. A large number of kinesin-type motorproteins mediates the interaction of microtubules with other molecules or organelles. The aim of this project is to characterize the function of selected motorproteins using molecular biology and biochemical approaches.
Applicants for both positions should have a strong background in molecular cell biology or biochemistry.
Applications from handicapped persons will be favoured when all other qualifications are equal. The university of Bayreuth is an equal opportunity employer and we therefore especially encourage women to apply.
Starting date: October 2011
Duration: 3 years (Salary E 13 TV-L/ 50%)
Please send applications, including a full CV, by email to:
Prof. Dr. Klaus Ersfeld
Department of Genetics
University of Bayreuth
95440 Bayreuth, Germany
email: klaus.ersfeld [a] uni-bayreuth[.]de
Tel: +49-(0)921-552726
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